Listening to the AIPLA presentation on patent eligibility a few weeks ago, it sounded as though one of the Federal Circuit cases that the PTO is watching is Ariosa Diagnostics, Inc. v. Sequenom, Inc. That case was argued on November 7, 2014 and has not yet been decided.
The parties drew a thoughtful panel — judges Reyna, Linn, and Wallach.
You can listen to the oral argument here: [Listen].